Research progress in influencing factors for warfarin individualized medication
Received:July 15, 2020  
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Key words:warfarin; personalized medication; gene detection; genetic factors; non-genetic factors This work was supported by the Major Clinical Projects of Department of Science and Technology of Jiangsu Province
Author NameAffiliationE-mail
SHAN Guang-Dong First Clinical College, Dalian Medical University, Dalian 116000, Liaoning Province, China 
GU Xiang Department of Cardiology, Northern Jiangsu People′s Hospital, Yangzhou 225001, Jiangsu Province, China 
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      Warfarin, as well as other vitamin K antagonists, is the most widely used anticoagulant drug currently in clinical practice, and is mainly used to prevent thrombotic events due to heart valve replacement, atrial fibrillation and other diseases. However, there are many factors affecting its clinical efficacy, and the effective dose of warfarin varies greatly among individuals. With the in-depth study of warfarin pharmacogenomics, individualized warfarin medicine has gradually become possible. At present, the use of warfarin under genetic guidance is still controversial. This article reviewed the non-genetic factors and genetic factors that affect warfarin dose variation in order to provide a reference for disease precision treatment.