Clinicopathological characteristics of hyperglycemic elderly patients with colorectal cancer and analysis on postoperative complications
Received:August 30, 2020  
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DOI:10.11915/j.issn.1671-5403.2021.07.103
Key words:aged; hyperglycemia; colorectal cancer; pathological features; postoperative complications This work was supported by the Project of Science and Technology Plan of Xuzhou, Jiangsu Province
Author NameAffiliationE-mail
XU Min Graduate School of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China;General Hospital of Eastern Theater Command of Chinese People′s Liberation Army, Nanjing 210002, China yrl6502@sina.comclinicopathological 
LI Xing-Wang Graduate School of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China yrl6502@sina.comclinicopathological 
LU Hai-Long Department of Geriatrics, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China yrl6502@sina.comclinicopathological 
YANG Rong-Li Department of Geriatrics, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221004, Jiangsu Province, China yrl6502@sina.comclinicopathological 
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Abstract:
      Objective To study the relationship of hyperglycemia with clinical pathological features and postoperative complications of colorectal cancer in the elderly. Methods Clinical data of 78 elderly patients with colorectal cancer in the Affiliated Hospital of Xuzhou Medical University from July 2019 to July 2020 were retrospectively collected in this study. They were and divided into hyperglycemia group (n=36) and normal blood glucose group (n=42) according to blood glucose level. The clinical data, pathological indexes, tumor markers and postoperative complications were compared between the 2 groups. SPSS statistics 24.0 was used for statistical analysis. Data comparison between 2 groups was performed using Chi-square test, student′s t test, Wilcoxon test, Fisher exact probability test or Kruskal-Wallis test depending on date types. Results There were significant differences in body mass index (BMI) and first symptoms between the 2 groups (both P<0.05). In the hyperglycemia group, tumor masses were mostly located in the left colon, while in the normal glucose group, majorly in the right colon, and statistical difference was seen in the site (P<0.05). The tumor stage of the hyperglycemia group was generally in stage Ⅲ and Ⅳ, that of normal glucose group was in stage Ⅱ and Ⅲ (P<0.05), but lymph node metastasis was quite common in the former group (P<0.05). The hyperglycemia group had significantly higher preoperative levels of carcinoembryonic antigen (CEA) and CA199 when compared with the normal glucose group (P<0.05), but no such differences were observed in the preoperative levels of CA125, CA242, CA724 and CA50 and postoperative levels of CEA, CA125, CA199, CA242, CA724 and CA50 between the 2 groups (all P>0.05). The preoperative CEA level differed in different pathological stages (P<0.05), but such difference was only observed in the hyperglycemia group (P<0.05), not in the normal glucose group (P>0.05). The hyperglycemia group had notably higher incidence rate of postoperative complications than the other group [33.4% (12 cases) vs 28.7% (12 case), P<0.05]. Conclusion Hyperglycemia is a risk factor for colorectal cancer in the elderly. Health education on blood glucose control can reduce the postoperative infection rate in these patients.
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