Research progress of long non-coding RNAs in regulation of inflammatory signal pathways in gout
Received:December 17, 2018  
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DOI:10.11915/j.issn.1671-5403.2019.06.100
Key words:long non-coding RNAs; gout; inflammation; signal pathway
Author NameAffiliationE-mail
YANG Yan-Yu Department of Geriatrics, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China  
XIONG Qin Department of Geriatrics, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China  
TAN Min Department of Geriatrics, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China  
QUAN Ya-Ping Department of Geriatrics, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China  
ZHANG Quan-Bo Department of Geriatrics, the Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China quanbozhang@126.com 
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Abstract:
      Long non-coding RNAs(LncRNAs)are defined as a non-coding RNAs with no protein coding capability which are composed of over 200 nucleotides. With the rapid development of gene sequencing and gene chip, a growing number of studies have shown that LncRNAs are involved in the pathogenesis of many diseases in humans by regulating cellular immunity, epigenetics, gene transcription and post-transcriptional regulation for gene expression regulation. In recent years, with the change of living habits and dietary structure, the incidence of gout is on the rise. More studies have shown that LncRNAs play an important role in the pathogenesis of gout, especially in regulating inflammatory signaling pathways which are associated with gout. This article reviews the relationship of LncRNAs and inflammatory signaling pathways which were associated with gout, in order to further reveal the pathogenesis of gout and provide new methods for early prevention and treatment of gout and its complications.
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