Correlation of mitochondrial dysfunction and inflammation with aging
Received:December 23, 2018  
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DOI:10.11915/j.issn.1671-5403.2019.06.099
Key words:inflammation; aging; mitochondria dysfunction; mitochondrial DNA; oxidative stress
Author NameAffiliationE-mail
LIU Jun-Le Department of Anesthesiology, Union Hospital, Fujian Medical University, Fuzhou 350001, China  
ZHANG Liang-Cheng Department of Anesthesiology, Union Hospital, Fujian Medical University, Fuzhou 350001, China zhanglc6@163.com 
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Abstract:
      Mitochondrial dysfunction and inflammation are signs of aging and chronic degenerative diseases. Mitochondrial dysfunction may be the initiating factor of aging in which process oxidative mitochondrial DNA damage occurs at varying degrees, resulting in impaired energy metabolism, cell dysfunction, and even death of cells. At the same time, the persistent low-level inflammatory response of aging organisms can impair the activation of the immune system through a variety of functions and the role of inflammatory metabolites in regulating immune response also can provide evidence for intervening the pathological process of age-related diseases.
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