Research progress on mechanism of atherosclerosis induced by trimethylamine-N-oxide
Received:May 01, 2018  
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DOI:10.11915/j.issn.1671-5403.2019.02.031
Key words:atherosclerosis; trimethylamine-N-oxide; intestinal microbiota
Author NameAffiliationE-mail
JIANG Xiao-Yan Department of Cardiology, Second Hospital of Hunan Normal University, Changsha 410003, China  
DUAN Jia-Huai Department of Cardiology, Second Hospital of Hunan Normal University, Changsha 410003, China;Department of Nutrition, the 1203452224@qq.com 
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Abstract:
      More and more studies have shown that the intestinal microbiota are significantly associated with atherosclerosis. The nutrients such as lecithin, choline and carnitine in food are metabolized by the intestinal microbiota, and their metabolite trimethylamine-N-oxide (TMAO) may contribute to atherosclerosis. Its mechanism is not fully understood, but such a view provides a new orientation for research on atherosclerosis and other cardiovascular and cerebrovascular diseases. In this review, we summarized research on the mechanisms of TMAO-induced atherosclerosis in recent years.
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