Research progress in relation of iron oxidative stress and cerebrovascular diseases
Received:May 02, 2018  Revised:July 16, 2018
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DOI:10.11915/j.issn.1671-5403.2019.01.018
Key words:leukoaraiosis; cerebral infarction; cerebral hemorrhage; cerebrovascular diseases; iron overload; serum ferritin; oxidative tress
Author NameAffiliationE-mail
WANG Li-Jiao Department of Geriatrics, Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China  
FAN Ying Department of Geriatrics, Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China fanyingyan@163.com 
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Abstract:
      Serum ferritin, an important indicator of iron metabolism and iron storage in the body, can be used as a marker for inflammation, anemia and tumor. Iron overload results in increased serum ferritin, and excessive iron can generate excessive free radicals through Fenton reaction, which can contribute to occurrence of vascular diseases through oxidative stress, lipid metabolism and atherosclerosis. In this paper, we reviewed the status quo of the research on iron oxidative stress in cerebral infarction, cerebral hemorrhage and leukoaraiosis in a view to finding a way to prevent and treat cerebrovascular diseases in consideration of oxidative stress of iron.
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