Advances in research on the therapeutic potential of hydrogen sulfide and its exogenous donors in cardiovascular diseases
Received:June 22, 2019  Revised:July 21, 2019
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Key words:hydrogen sulfide; cardiovascular disease; atherosclerosis; cardiac hypertrophy; heart failure; ischemia/reperfusion injury
Author NameAffiliationE-mail
LI Tian-Tian 佳木斯大学附属第一医院心内三科 
GUO Li 佳木斯大学附属第一医院心内三科  
张书虎 哈尔滨医科大学附属第二医院老年医学科 
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      Hydrogen sulfifide (H2S) is considered to be the third largest endogenous gas signaling molecule after CO and NO. It can be synthesized in mammalian tissues and can freely pass throughthe cell membrane, including the cardiovascular system.A variety of biological effects are exerted in multiple systems including the cardiovascular system.Cardiovascular disease is the leading cause of death worldwide, and its specific pathogenesis is not fully understood.In recent years, more and more studies have supported the protective effects of endogenous H2S and exogenous H2S donor compounds (such as NaHS、Na2S and GYY4137) on cardiovascular diseases such as atherosclerosis, myocardial h-ypertrophy, heart failure and ischemia/reperfusion injury.This article reviews the research progress in this area, highlighting the potential of H2S and various e-xogenous H2S donors in the treatment of cardiovascular disease.