Risk factors of frailty syndrome in the elderly among community
Received:February 13, 2019  Revised:April 17, 2019
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Key words:frailty syndrome; elderly; chronic inflammation;comorbidity
Author NameAffiliationE-mail
GUO Zhao-Huan 空军军医大学西京医院 1057651838@qq.com 
侯莉明 空军军医大学西京医院 13319189560@163.com 
WANG Xiao-Ming 空军军医大学西京医院 xmwang@fmmu.edu.cn 
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      Objective Frailty syndrome is an important geriatric syndrome, and its mechanism is still unclear. This study intends to explore the possible risk factors of the frailty syndrome in the elderly. Methods Using the FRAIL scale, 153 patients with FRAIL syndrome aged 65 years or older were screened from October 2017 to October 2018 in a community health service center in Xi’an, and 174 people with non-frail syndrome aged 65 years or older were selected at the same time. Socio-demographic, lifestyle and diseases of the elderly were collected, and the levels of inflammatory cytokines (TNF-α, CRP) in serum were detected by Elisa Kits. Results (1) The levels of chronic inflammation were significantly higher in the frailty group[TNF-α: 19.38±1.51 ng/L vs 12.72±2.10 ng/L; CRP: 4.74±1.13 mg/L vs 3.39±0.58 mg/L; P<0.01]; (2) The correlation analysis showed that the FRAIL group's integrated score was positively correlated with weight(r=0.129,P<0.05), waist (r=0.196,P<0.01), BMI(r=0.135,P<0.05), comorbidity(r=0.621,P<0.01), TNF-α(r=0.304,P<0.01), CRP(r=0.596,P<0.01); (3) Step-wise regression analysis showed that comorbidity, chronic inflammation (TNF-α, CRP) were the risk factors of frailty syndrome in elderly population (R2=0.507). Conclusion Overweight, comorbidity and the levels of chronic inflammation were the risk factors of frailty among the community elderly.