A study on percentage of monocytes in peripheral blood of patients with Alzheimer’s disease with neuropsychiatric symptoms
Received:November 15, 2018  Revised:January 02, 2019
View Full Text  View/Add Comment  Download reader
DOI:
Key words:Alzheimer’s disease;behavioral and neuropsychiatric symptoms of dementia;monocytes
Author NameAffiliationE-mail
Gao Wen-chao Beijing Geriatric Hospital 15201304227@163.com 
Hits: 23
Download times: 
Abstract:
      Objective To investigate the percentage of monocytes in peripheral blood of patients with Alzheimer’s disease with neuropsychiatric symptoms. Methods A total of 74 patients diagnosed with AD were recruited between January and October 2018. 37 patients with behavioral and psychological symptoms of dementia (BPSD)were assigned to BPSD group,and 37 patients without BPSD were assigned to control group. Neuropsychiatric Inventory (NPI ) was used to assess the severity of BPSD of all the participants and 5ml venous blood was drew from all the participants when they were admitted. The percentage and quantity of the monocytes was measured and recorded,and the same procedure was repeated after one month’s of therapy. The data were analyzed. Results The percentage of monocytes of BPSD group was higher than that of the control group when they were admitted[(8.56±0.92)vs(5.36±0.32);P<0.05] .In the BPSD group,both the NPI score[(26.49±6.17)vs(45.89±7.78);P<0.05]and the percentage of monocytes [(5.54±0.41)vs(8.56±0.92);P<0.05] decreased after they were treated for 1 month,but the percentage of monocytes after being treated was higher than that of control groups[(5.54±0.41)vs(5.33±0.33);P<0.05],while the the percentage of monocytes of control group didn’t change obviously (P>0.05). The percentage of monocytes of BPSD group before and after being treated was significantly associated with the NPI score (r=0.736,P<0.05;r=0.579,P<0.05). Conclusion The percentage of monocytes in peripheral blood of patients with AD was significantly associated with the NPI score.
Close