Prediction value of NGAL level for contrast-induced nephropathy after intervention treatment for coronary heart disease
Received:December 11, 2018  Revised:December 17, 2018
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Key words:coronary atherosclerotic heart disease; neutrophil gelatinase associated lipocalin;contrast-induced nephropathy
Author NameAffiliationE-mail
gaoyi-bing 南京医科大学第二附属医院急诊科 power870310@126.com 
wangdi-bin 南京医科大学第二附属医院心内科 wjm417@163.com 
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Abstract:
      Abstract: Objective To observe the changes of blood neutrophil gelatinase-associated lipocalin (NGAL) level in patients with coronary heart disease after intervention treatment and to investigate its prediction value for contrast-induced nephropathy (CIN). Methods 136 patients underwent CAG or PCI were enroll in this study. There were 10 patients with CIN in CIN group and 126 patients without CIN in non-CIN group .The levels of serum creatinine(Cr),blood urea nitrogen(BUN) and blood NGAL were measured before and after the operation. The prediction value of blood NGAL for CIN was estimated by receiver operating characteristic (ROC) curve analysis. Results The results showed that the difference of Cr and BUN after 48h between CIN group and non-CIN group was statistically significant(p<0.05). The NGAL level which samples were collected after 24h was statistically significant(p<0.05) between CIN group and non-CIN group. The Cr level which samples were collected after 24h was not statistically significant(p<0.05) between CIN group and non-CIN group. The levels of blood NGAL were positively correlated with serum levels of Cr and BUN at 48 h after operation ( all p<0.01).At 24 hours after operation the AUCs were calculated as 0.852±0.087 for blood NGAL and 0.550±0.107 for serum Cr at 48 h after operation the AUCs were calculated as 0.990±0.008 for blood urea nitrogen. When we choose Blood NGAL value as 40.325ng/ml for diagnosis for CIN, the sensitivity was 70% and specificity was 100%. Conclusion Blood NGAL 24h after coronary intervention can be used as a prediction of CIN,
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